The serial CMOS interface supports the data output with 2-wire, 1-wire and 1/2-wire operation. The actual data output rate depends on the output resolution and number of lanes used.

The ADC3660 requires an external serial clock input (DCLKIN), which is used to transmit the data out of the ADC along with the data clock (DCLK). The phase relationship between DCLKIN and the sampling clock is irrelevant but both clocks need to be frequency locked. The serial CMOS interface is configured using SPI register writes.