The two channels of the INA2126 are completely independent, including all bias circuitry. At dc and low frequency, there is virtually no signal coupling between channels. Crosstalk increases with frequency and depends on circuit gain, source impedance, and signal characteristics.

As source impedance increases, careful circuit layout can help achieve lowest channel crosstalk. Most crosstalk is produced by capacitive coupling of signals from one channel to the input section of the other channel. To minimize coupling, separate the input traces as far as practical from any signals associated with the opposite channel. A grounded guard trace surrounding the inputs helps reduce stray coupling between channels. Carefully balance the stray capacitance of each input to ground, and run the differential inputs of each channel parallel to each other, or directly adjacent on top and bottom side of a circuit board. Stray coupling then tends to produce a common-mode signal that is rejected by the IA input.