The recommended bias supply voltage range for LM5110 is from 3.5 V to 14 V. The upper end of this range is driven by the 15 V absolute maximum voltage rating of the VCC. TI recommends keeping proper margin to allow for transient voltage spikes.

A local bypass capacitor must be placed between the VCC and IN_REF pins, as well as between the VCC and VEE. This capacitor must be placed as close to the device as possible. A low ESR, ceramic surface mount capacitor is recommended. TI recommends using 2 capacitors in parallel: a 100-nF ceramic surface-mount capacitor for high frequency filtering placed as close to VCC as possible, and another surface-mount capacitor, 220 nF to 10 µF, for IC bias requirements.