The LMH6881 was designed to be operated on 5-V power supplies. The voltage range for VCC is from 4.75 V to 5.25 V. Power-supply accuracy of 5% or better is advised. When operated on a board with high-speed digital signals it is important to provide isolation between digital signal noise and the analog input pins. The SP16160CH1RB reference board provides an example of good board layout.

The power supply pins are 19, 20, 23 and 24. Each supply pin should be decoupled with a low-inductance, surface-mount ceramic capacitor of approximately 10 nF as close to the device as possible. When vias are used to connect the bypass capacitors to a ground plane the vias should be configured for minimal parasitic inductance. One method of reducing via inductance is to use multiple vias. For broadband systems two capacitors per supply pin are advised.

To avoid undesirable signal transients the LMH6881 should not be powered on with large inputs signals present. Careful planning of system power on sequencing is especially important to avoid damage to ADC inputs when an ADC is used in the application.