The MUX50x operates across a wide supply range of ±5 V to ±18 V (10 V to 36 V in single-supply mode). The devices also perform well with unsymmetric supplies such as V_DD = 12 V and V_SS= –5 V. For reliable operation, use a supply decoupling capacitor ranging between 0.1 µF to 10 µF at both the VDD and VSS pins to ground.

The on-resistance of the MUX50x varies with supply voltage, as illustrated in Figure 44

Figure 44. On-Resistance Variation With Supply and Input Voltage