The OPA165x are specified for operation from 4.5 V to 36 V (±2.25 V to ±18 V); many specifications apply from
–40°C to +125°C. Parameters that can exhibit significant variance with regard to operating voltage or temperature are presented in the Typical Characteristics section.

The OPA165x operate with as little as 4.5 V between the supplies and with up to 36 V between the supplies. However, some applications do not require equal positive and negative output voltage swing. With the OPA165x, power-supply voltages are not required to be equal. For example, the positive supply can be set to 25 V with the negative supply at –5 V.