The OPA454 may be operated from power supplies up to ±50 V or a total of 100 V with excellent performance. Most behavior remains unchanged throughout the full operating voltage range. Parameters that vary significantly with operating voltage are shown in Typical Characteristics.

Some applications do not require equal positive and negative output voltage swing. Power-supply voltages do not need to be equal. The OPA454 can operate with as little as 10 V between the supplies and with up to 100 V between the supplies. For example, the positive supply could be set to 90 V with the negative supply at –10 V, or vice-versa (as long as the total is less than or equal to 100 V).