The SN74AVC4T245-Q1 device uses two separate configurable power-supply rails: V_CCA and V_CCB. V_CCA accepts any supply voltage from 1.2V to 3.6V, and V_CCB accepts any supply voltage from 1.2V to 3.6V. The A port and B port are designed to track V_CCA and V_CCB respectively, allowing for low-voltage bidirectional translation between any of the 1.2V, 1.5V, 1.8V, 2.5V, and 3.3V voltage nodes.

The output-enable (OE) input circuit is designed so that it is supplied by V_CCA; when the OE input is high, all outputs are placed in the high-impedance state. To place the outputs in the high-impedance state during power up or power down, tie the OE input pin to V_CCA through a pullup resistor and do not enable it until V_CCA and V_CCB are fully ramped and stable. The minimum value of the pullup resistor to V_CCA is determined by the current-sinking capability of the driver.