All communications to the TAS6424E-Q1 are through the I²C protocol. A system controller can communicate with the device through the SDA pins and SCL pins. The device is an I²C secondary and requires a primary. The device cannot generate an I²C clock or initiate a transaction. The maximum clock speed accepted by the device is 400 kHz. If multiple TAS6424E-Q1devices are on the same I²C bus, the I²C address must be different for each device. Up to four TAS6424E-Q1 devices can be on the same I²C bus.

The I²C bus is shared internally.