The TCA39416 has no supply restrictions outside of the 0.72 V to 1.98 V range. V_CCA must be ≤ V_CCB for proper operation.

The sequencing of each power supply does not damage the device during the power up operation, so either power supply can be ramped up first. The output-enable (OE) input circuit is designed so that when the (OE) input is low, the outputs are disabled. No signals may propagate the rise time and fall time accelerators, and the internal pull up resistors are disabled. To make sure the signals do not pass through during power up or power down, the OE input pin must be tied to GND through a pull down resistor. The OE input pin should not be enabled until V_CCA and V_CCB are fully ramped and stable. If OE is tied to V_CCA, this is OK, but might result in a glitch on the bus during power up depending on the capacitive load and ramp rates. The minimum value of the pull down resistor to ground is determined by the current-sourcing capability of the driver.