Each switch input can be programmed to enable or disable interrupt generation upon status change by configuring registers INT_EN_COMP1 to INT_EN_COMP2 (for comparator inputs) and INT_EN_CFG1 to INT_EN_CFG4 (for ADC inputs). Interrupt generation condition can be adjusted for THRES_COM (for IN0-IN11) by adjusting the IN_COM_EN bit in the MATRIX register.

The abovementioned registers can also be used to control interrupt generation condition based on the following settings:

1. Rising edge: an interrupt is generated if the current input measurement is above the corresponding threshold and the previous measurement was below.
2. Falling edge: an interrupt is generated if the current input measurement is below the corresponding threshold and the previous measurement was above.
3. Both edges: changes of the input voltage in either direction results in an interrupt generation.

Note interrupt generation from switch status change is disabled for all inputs by default upon device reset.