The TMUX7462F is a four-channel protector that can be placed in series with the signal path to protect sensitive components downstream from overvoltage faults. The channel protector prevents overvoltages in both powered and powered-off conditions, making it suitable for applications where correct power supply sequencing cannot be precisely controlled. The powered-off condition includes floating power supplies, grounded power supplies, or power supplies at any level that are below the undervoltage (UV) threshold. The internal switch is turned-on and turned-off autonomously based on the fault situation without the need of external controls, making the device extremely easy to implement in the system. The primary supply voltages define the on-resistance profile, while the secondary supply voltages define the voltage level at which the overvoltage protection engages. The device works well with dual supplies (±5 V to ±22 V), a single supply (8 V to 44 V), or asymmetric supplies (such as V_DD = 12 V, V_SS = –5 V).