The TPS544C26 device offers both I²C interface and SVID interface for programming and telemetry report. The device supports a group of I²C registers which is listed in . The device also supports a subset of the SVID registers listed in .

For I²C interface, the TPS544C26 device supports minimum 50 kHz and maximum 1 MHz operating frequency range, with the support of the Standard-mode, Fast-mode, and Fast-mode Plus bus timing requirements.

The high threshold of I²C SCL and SDA pin is 0.585 V typical, and the low threshold of I2C SCL and SDA pin is 0.515 V typical.

The TPS544C26 device contains nonvolatile memory that is used to store user-accessible configurations. The settings programmed into the device are not automatically saved into this nonvolatile memory. The (15h) STORE_USER_ALL command must be used to commit the current I²C settings to nonvolatile memory as device defaults. For example, after importing a group of settings from a user specific configuration file the (15h) STORE_USER_ALL command must be used to save the settings into the nonvolatile memory. The settings that are capable of being stored in nonvolatile memory are noted in their detailed descriptions.