The TXS0101 device uses two separate configurable power-supply rails, V_CCA and V_CCB. V_CCB accepts any supply voltage from 2.3 V to 5.5 V and V_CCA accepts any supply voltage from 1.65 V to 3.6 V as long as Vs is less than or equal to V_CCB. The A port and B port are designed to track V_CCA and V_CCB respectively allowing for low voltage bidirectional translation between any of the 1.8 V, 2.5 V, 3.3 V, and 5 V voltage nodes.

The TXS0101 device does not require power sequencing between V_CCA and V_CCB during power-up so the power-supply rails can be ramped in any order. A V_CCA value greater than or equal to V_CCB (V_CCA ≥ V_CCB) does not damage the device, but during operation, V_CCA must be less than or equal to V_CCB (V_CCA ≤ V_CCB) at all times.

The output-enable (OE) input circuit is designed so that it is supplied by V_CCA and when the (OE) input is low, all outputs are placed in the high-impedance state. To ensure the high-impedance state of the outputs during power up or power down, the OE input pin must be tied to GND through a pulldown resistor and must not be enabled until V_CCA and V_CCB are fully ramped and stable. The minimum value of the pulldown resistor to ground is determined by the current-sourcing capability of the driver.