Analog designers are frequently required to develop circuits that convert high-voltage signals to levels acceptable for low-voltage data converters. This paper describes several solutions for this common task using modern amplifiers and typical power supplies. Five examples of conditioning ±10V bipolar signals for low-voltage, single-rail analog-to-digital converters (ADCs) are presented: a modular approach, a single-supply/single-part approach, and an instrumentation amplifier approach. Both single-ended, differential input versions are discussed.