When the EN pin of the TMUX7208 is pulled high, one of the switches is closed based on the state of the Ax pin. Similarly, when the EN pin of the TMUX7209 is pulled high, two of the switches are closed based on the state of the address lines. When the EN pin is pulled low, all of the switches are in an open state regardless of the state of the Ax pin. The control pins can be as high as 44 V.

The TMUX7208 and TMUX7209 can be operated without any external components except for the supply decoupling capacitors. The EN and Ax pins have internal pull-down resistors of 4 MΩ. If unused, Ax and EN pins must be tied to GND in order to ensure the device does not consume additional current as highlighted in Implications of Slow or Floating CMOS Inputs. Unused signal path inputs (Sx or D) should be connected to GND.