To operate the EVM as single supply, connect both the Vs- and GND connectors to ground, and apply the positive-supply voltage to Vs+. In this configuration, a populated output loads (C7, C7, R10, and R21) can present a DC load to ground for the amplifier as they are not referenced to mid-supply in the single-supply configuration. Additionally, the input resistors (R7, R13, R18, and R24) may pull the inputs of the amplifier to ground depending on the configuration. It is important to be aware of any device limitations in the mode of operation.