The TPS65263 requires a start condition, a valid I²C address, a register address byte, and a data byte for a single update. After the receipt of each byte, TPS65263 device acknowledges by pulling the SDA line low during the high period of a single clock pulse. A valid I²C address selects the TPS65263. TPS65263 performs an update on the falling edge of the LSB byte.

When the TPS65263 is in hardware shutdown (EN1, EN2, and EN3 pin tied to ground) the device cannot be updated through the I²C interface. Conversely, the I²C interface is fully functional during software shutdown (EN1, EN2, and EN3 bit = 0).

Figure 8-13 I²C Write and Read Data Format