The AMC3302 requires a single 3.3-V or 5-V supply on its low side. The high-side supply is internally generated by an integrated DC/DC converter, as explained in the Section 7.3.4 section.

The ground reference (HGND) is derived from the terminal of the shunt resistor that is connected to the negative input (INN) of the AMC3302. If a four-pin shunt is used, the inputs of the device are connected to the inner leads and HGND is connected to one of the outer leads. To minimize offset and improve accuracy, set the ground connection to a separate trace that connects directly to the shunt resistor rather than shorting HGND to INN directly at the input to the device. See the Section 10 section for more details.