The TMUX646 can be properly operated without any external components. However, TI recommends that unused I/O signal pins be connected to ground through a 50 Ω resistor to prevent signal reflections and maintain device performance. The NC pins of the device do not require any external connections or terminations and have no connection to the rest of the device internally.

The clock and data lanes can be interchanged as necessary to facilitate the best layout possible for the application. For example, the clock can be placed on the D1 channel and a data lane can be used on the CLK channel if this improves the layout. In addition, the signal lines of the TMUX646 are routed single ended on the chip die. This makes the device suitable for differential and single-ended high-speed systems.