This application report describes the benefits of cryptographic acceleration and provides performance and energy consumption measurements of on-chip cryptographic accelerators integrated in the SimpleLink CC13x2/CC26x2 family of wireless microcontrollers (MCUs). It also benchmarks these measurements against Arm®Cortex®-M4F software-based implementations of cryptographic operations. This document also describes device power management and TI driver concepts to consider for enabling efficient usage of SimpleLink cryptographic drivers.